OBJECTIVE
The primary objective was to compare the contamination between barrier and filterbased closed-system transfer devices
METHODS
- Two barrier-based (Equashield® and PhaSeal™) and two filter-based (Tevadapter® and ChemoClave®) CSTDs were used to manipulate ten samples each of ifosfamide, methotrexate, and etoposide
- Three manipulations performed at approximately 0, 4-6, and s24 hours for each drug-device combination
- After each manipulation, the vial/vial adapter was disconnected from the syringe/syringeadapter and the membranes were wiped with a ChemoGLO™ wipe
- Once all three manipulations had been completed, each bag was opened and wiped using ChemoGLO™ wipes
- Before opening a new drug-device combination, the laminar flow hood was wiped using ChemoGLO™ HDCIean wipes
- Completed ChemoGLO™ Wipe Kits were sent to ChemoGLO™ to be analyzed using LC-MS technology
- Student’s t-test was used for two-way comparisons and two-way ANOVA for comparison of average contamination among devices
CONCLUSIONS
- Barrier-based devices are associated with significantly less HD contamination than filterbased devices
- There was significant contamination when using PhaSeal™ with ifosfamide manipulations
- Potentially, there are unstudied chemical characteristics of HDs that affect the performance of CSTDs
- Compared to all other CSTDs, Equashield®
- had significantly lower contamination than all other CSTDs tested
- The smoke test and 70% isopropyl alcohol vapor test do not adequately assess the effectiveness in controlling HD contamination
- Further studies are needed to fully elucidate the effects of various HDs on CSTD performance
DISCLOSURE
The authors of this presentation have the following disclosures concerning possible financial or personal relationships with commercial entities:
- Joseph Arminger, BS, PharmD- No Disclosures
- Alyson Leonard, PharmD, BCPS- No Disclosures
- Adam Peele, PharmD. MHA, BCPS. BCOPNo Disclosures
- Crystal Peyton, BS, CPhT- No Disclosures Funding provided by Equashield, LLC
RESULTS
Table 1: Average contamination stratified by device and HD
Table 2: Summary of primary and secondary outcome results
