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Medical personnel have been examining the issues of exposure to hazardous medications and prevention. Malformations, spontaneous abortions, and stillbirths have been associated with exposures to cytostatic agents. Closed-system drug transfer devices are recommended by the National Institute for Occupational Safety and Health (NIOSH) for the containment of hazardous drugs. The purpose
of this study is to examine available products utilized for drug-transfer to determine which device prevents the escape of vapor meeting the NIOSH definition of closed.
Titanium tetrachloride (TiCl4) was used to simulate gas-containing active drug. Titanium tetrachloride generates very visible smoke when it comes into contact with moisture in the air. It was placed into glass vials attached to the above transfer devices to determine which system prevents the escape of vapor.
Only the PhaSeal® System prevented the release of titanium smoke out of the closed-system drug transfer device. Only the PhaSeal® System met the NIOSH definition of a closed-system drug transfer device.
National Institute for Occupational Safety and Health. NIOSH alert: preventing occupational exposure to antineoplastic and other hazardous drugs in health care settings. www.cdc.gov/niosh/docs/2004-165/pdfs/2004-165.pdf American Society of Health System Pharmacists. ASHP guidelines on handling hazardous drugs. Am J Health-Syst Pharm. 2006; 63: 1172-93.
Medical personnel have been examining the issues of exposure to hazardous medications and prevention. Malformations, spontaneous abortions, and stillbirths have been associated with exposures to cytostatic agents. Closed-system drug transfer devices are recommended by the National Institute for Occupational Safety and Health (NIOSH) for the containment of hazardous drugs. The purpose
of this study is to examine available products utilized for drug-transfer to determine which device prevents the escape of vapor meeting the NIOSH definition of closed.
Titanium tetrachloride (TiCl4) was used to simulate gas-containing active drug. Titanium tetrachloride generates very visible smoke when it comes into contact with moisture in the air. It was placed into glass vials attached to the above transfer devices to determine which system prevents the escape of vapor.
Only the PhaSeal® System prevented the release of titanium smoke out of the closed-system drug transfer device. Only the PhaSeal® System met the NIOSH definition of a closed-system drug transfer device.
National Institute for Occupational Safety and Health. NIOSH alert: preventing occupational exposure to antineoplastic and other hazardous drugs in health care settings. www.cdc.gov/niosh/docs/2004-165/pdfs/2004-165.pdf American Society of Health System Pharmacists. ASHP guidelines on handling hazardous drugs. Am J Health-Syst Pharm. 2006; 63: 1172-93.
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