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A liquid with low pH was used as a substitute for active drug. Litmus paper was used as a pH indicator. Blue litmus paper turns red under acidic conditions.
Syringes were filled with fluid and injected into vials attached to the above transfer devices. After aspirating back and disconnecting, the connections of each device were pressed against litmus paper to detect the presence of any fluid.
Every component of each device was tested for 10 manipulations.
Visible leakage occurred outside of the components on the ICU Medical System SpirosTM and Clave® connections, the B. Braun OnGuardTM System and the Cardinal Health/Alaris System during all manipulations.
No leakage was observed in any of the manipulations with the PhaSeal® System by Carmel Pharma.
Spiros™ Male Connector & Clave® by ICU Medical Inc.
B. Braun OnGuard™ Vial Adaptor & Syringe Adaptor by Teva Medical Ltd.
Alaris SmartSite® Vented Vial Access Device & Texium™ Male Luer by Cardinal Health
PhaSeal® Protector & Injector Luer Lock by Carmel Pharma
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