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featured image - Superior Safety and Ease of Use

Superior Safety and Ease of Use

featured image - The Premium Equashield CSTD offers Superior Safety and Ease-of-Use

The Premium Equashield CSTD offers Superior Safety and Ease-of-Use

for the compounding and administration of hazardous drugs, backed with clinically substantiated data on reduction of surface contamination with antineoplastic agents[1][1] Clark Bernadette A. and Sessink Paul JM. “Use of a closed system drug-transfer device eliminates surface contamination with antineoplastic agents.” Journal of Oncology Pharmacy Practice 2013and is faster to compound a dose than alternative systems [2].[2] Berdi F, Powell M, Sanz C, et al. “Assessing the efficiency of CSTDs for compounding”. PP&P Journal. 2015; 7(suppl):S4-S10Used by the number one hospital in both Europe and U.S., Equashield® covers more routes of exposure than alternative systems and is substantiated to FDA and defined in FDA’s ONB code cleared labeling as Preventing Microbial Ingress up to 7 days[*][*] Equashield® does not extend the sterility and expiration date of the drug beyond manufacturer recommendations. Please refer to individual drug labeling or USP compounding guidelines for beyond use dating of a drug.

featured image - Covers More Routes of Exposure
Encapsulated plunger
No Plunger Contamination
Undetachable Plunger

Covers More Routes of Exposure

Equashield’s proprietary Syringe Unit has an airtight enclosure that encapsulates the syringe barrel, isolates the unique syringe plunger rod and provides the flawless in use feeling. Equashield’s unique design it is the only system that prevents syringe plunger contamination by hazardous drugs, which is a major route of exposure during routine drug preparations and IV pushes. Studies in the U.S.[3.4][3] Stephen T Smith et al. “Syringe plunger contamination by hazardous drugs: A comparative study”. Journal of Oncology Pharmacy Practice 2014.[4] Fouzia Berdi et al. “Evaluation of syringes used for compounding hazardous drugs and the contamination risks to healthcare personnel”. ASHP Midyear clinical meeting 2014. and Europe[5][5]Bertrand Favier et al. “Contamination of syringe plungers during the sampling of cyclophosphamide solutions”. Journal of Oncology Pharmacy Practice 2005. provide substantial scientific evidence for the presence of high levels of drug residuals (Cyclophosphamide) on the exposed plungers and open barrels of regular syringes. In turn, this exposure contaminated gloves and other work environment, whereas in the same studies[3.4][3] Stephen T Smith et al. “Syringe plunger contamination by hazardous drugs: A comparative study”. Journal of Oncology Pharmacy Practice 2014.[4] Fouzia Berdi et al. “Evaluation of syringes used for compounding hazardous drugs and the contamination risks to healthcare personnel”. ASHP Midyear clinical meeting 2014. no contamination was detected on Equashield® plungers.Unlike standard syringes, Equashield® can be used safely even beyond its nominal capacity as the encapsulated plunger rod can never be detached from the syringe, preventing the potential for spill.

featured image - Quicker Compounding, while Preventing Spills
  • Equashield high speed
  • Others tested low speed
Time to compound

Quicker Compounding, while Preventing Spills

The connector is factory welded to the Equashield® Syringe Unit saving valuable setup time[2][2] Berdi F, Powell M, Sanz C, et al. “Assessing the efficiency of CSTDs for compounding”. PP&P Journal. 2015; 7(suppl):S4-S10. compared to time spent on opening two packages and assembling a connector onto an off the shelf syringe.Additionally, the welded Equashield® Syringe Unit prevents opportunity for luer disconnection and spills.

featured image - Nothing In – Nothing Out
Nothing In Nothing Out
Uncontaminated 7 days
Centered Spiking

Nothing In – Nothing Out

The Vial Adaptor’s elastic membrane port has been substantiated for up to 10 connections with the Syringe Unit without leaks or drug residuals on its surfaces[6][6] Migal Analytical Chemistry Laboratory 2009. “Fluorescent Evaluation of Dry Connections in the Equashield, Phaseal and Tevadaptor/Onguard CSTDs” and without transfer of environmental contaminants into the vial[7, 8].[7] Nelson Laboratories (Salt Lake City, UT) 2013/14. “A 7 Days Microbial Ingress Test of Single Use Vials Utilizing the Equashield® CSTD”[8] Milouda&Migal Laboratories 2014. “Evaluation of Equashield Close System Compatibility in Prevention of Environmental Contamination” The Equashield® system has been substantiated to the FDA and defined in FDA cleared labeling as Preventing Microbial Ingress for up to 7 days* [*] Equashield® does not extend the sterility and expiration date of the drug beyond manufacturer recommendations. Please refer to individual drug labeling or USP compounding guidelines for beyond use dating of a drug.. This is evident in the extreme tests performed, where the Vial Adaptor’s membranes of growth media filled vials were inoculated with bacteria and accessed up to 10 times during 7 days with a total of 770 Syringe Units[7].[7] Nelson Laboratories (Salt Lake City, UT) 2013/14. “A 7 Days Microbial Ingress Test of Single Use Vials Utilizing the Equashield® CSTD”The Vial Adaptor is further equipped with a unique telescoping mechanism that guides its spike to the center of the vial stopper and prevents angled spiking, correcting user errors and eliminating any need for space consuming assembly fixtures. Inside the Vial Adaptor there are two internal fluid channels; one for the drug and another for gases with an internal hydrophobic barrier to prevent passage of liquids.

featured image - Single Motion Connectors

Single Motion Connectors

Just a single straight motion is required to connect and disconnect any Equashield® components.The large flow channels in all system components enable quick transfers with just a little force.

featured image - 10 Dry Connections & Needle safe
Dry Connectors
Needle Safe
Safety Lock

10 Dry Connections & Needle safe

As the user connects the Syringe Unit to the Adaptor, membranes of both connection components are pressed and locked together. The locking mechanism then descends back into the Syringe Unit causing both membranes to be pierced by stationary internal needles. The needles are never exposed and remain fully shielded inside the housing and beyond reach at all times, preventing needle stick injuries.During disconnection, the needles wipe against the resealing membranes, preventing any contact between the drug and outer surface of the membranes, leaving the contact area dry and drug residual free.10 repeated activations of Equashield® connectors were substantiated to be free of leaks or drug residuals on external surfaces[6][6] Migal Analytical Chemistry Laboratory 2009. “Fluorescent Evaluation of Dry Connections in the Equashield, Phaseal and Tevadaptor/Onguard CSTDs” and for the prevention of the transfer of environmental contaminants into the system[7, 8].[7] Nelson Laboratories (Salt Lake City, UT) 2013/14. “A 7 Days Microbial Ingress Test of Single Use Vials Utilizing the Equashield® CSTD”[8] Milouda&Migal Laboratories 2014. “Evaluation of Equashield Close System Compatibility in Prevention of Environmental Contamination”The Equashield® system has been substantiated to the FDA and defined in FDA cleared labeling as Preventing Microbial Ingress up to 7 days*. [*] Equashield® does not extend the sterility and expiration date of the drug beyond manufacturer recommendations. Please refer to individual drug labeling or USP compounding guidelines for beyond use dating of a drug.

featured image - Closed Pressure Equalization Prevents the Escape of Vapors
Pressure Equalization
Internal Equalization

Closed Pressure Equalization Prevents the Escape of Vapors

One of the main routes of contamination is caused by expulsion of vapors, droplets and aerosols into the work environment caused by typical pressure variation during drug transfer. Filter based venting or air cleansing systems are unable to prevent the escape of toxic vapor out of the system. Equashield® constantly equalizes pressure inside the fully closed system, preventing the escape of vapors and aerosols out of the system[9, 10].[9] Migal Analytical Chemistry Laboratory 2009. “Comparative Study of Vapor Containment Efficiency of Hazardous Drug Transfer Devices”.[10] Milouda&Migal Laboratories 2014. “Evaluation of Equashield Close System Compatibility in Prevention of Environmental Contamination Alcohol vapor detection”The encapsulated dual chamber Syringe Unit offers a standard chamber in the front of the syringe for drug and an additional factory sealed sterile air chamber in the back of the syringe. Two needles for air-to-liquid exchange, communicate with each chamber respectively. As the syringe piston moves, one chamber's volume increases, while the other chamber's volume decreases by precisely the same amount. Consequently, any displacement of liquid from the vial is replaced by an equivalent volume of air from the air chamber into the vial. During reconstitution of drug powder the process is reversed; the short liquid needle injects liquid into the powder vial, while the long air needle offsets the overpressure by transferring air from the vial into the air chamber in the back of the syringe.No setup is needed as the pressure is automatically equalized with any manipulation of the system. Both air bubbles and drug can be ejected back into the vial at any time during the drug withdrawal process.

featured image - Dry Disconnection
Clean Surface

Dry Disconnection

During disconnection, retracting needles wipe against the resealing membranes. This prevents any contact between the drug and the outer membrane surface, leaving the contact area dry and free of residues.

featured image - Adaptors for All

Adaptors for All

A large variety of Equashield Adaptors, Connectors and Tubing sets are available for all envisioned transfer of drugs from any size vial into any size of IV Bag and IV pushes. Additionally primary and secondary tubing sets, Foley catheters and other complex procedures are available. Ultimately, all Equashield Adaptors share a common closed mechanism of connection and disconnection, a single smooth motion.Recognizing that there are variations among IV Bag manufacturers and that no one IV port fits all bags, only Equashield® produces two Spike Adaptors; one for regular ports and one for bags with larger ports. These port designs prevent the opportunity of accidental spike disconnection from IV bag reducing opportunity for leaks and spills.

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